No posts until March. Off to meet our new Granddaughter. Will be Email and Internet free until then.
To fill up the empty hours until I’m back, drug chemists should study the physical chemistry of protein/protein interaction, since that’s where most cellular work is done (and where new drugs should be useful). The interctions are multiple, transient and nonequivalent (the WordPress processor substituted this for nonCovalent).
An interesting paper made all 160,000 possible variants of 4 amino acids at the interface between two bacterial proteins [ Science vol. 347 pp. 673 – 677 ’15 ]. For bacterial histidine kinases mutating just 3 or 4 interfacial amino acids to match those in another kinase is enough to reprogram their specificity. The key amino acids are Ala284, Val285, Ser288, Thr289. The results were rather surprising.