p. 1004 — The nitrosoureas are known carcinogens. They form DNA adducts (not sure exactly what they are) and are used experimentally to produce random mutations. Could they be forming carbenes in vivo?
Also, how do you make N-Methyl N-nitroso urea? N-methyl, N-nitroso toluene sulfonic acid?
p. 1007 — I assume you make tosyl azide from tosyl chloride plus sodium azide
p. 1007 Rh2(OAc)4 — presumably the structure will be given in the next chapter.
p. 1014 “Spin flipping, which can occur only through collision with another molecule (solvent usually) is relatively slow on the time scale of molecular rotations . . . “ Well how slow? These numbers are known. Why not give them. Also why does a collision have to be involved for spin flipping to occur? I think this question has been answered before. Sorry about asking it again. How about another link to it.
p. 1016 Interesting bunch of natural products containing cyclopropanes. How does Nature actually manage their synthesis?
p. 1018 — How do you make N2-CO2Et? Possibly using the tosyl hydrazone?
p. 1023 — Metathesis at last. When I type it, I have to stop myself from typing an awful word I’ve had to type (and utter) for years — Metastasis.
p. 1024 — In the mechanism shown — why doesn’t the ‘carbene’ attached to Rh leave the Ru and form a cyclopropane with the other olefin?
Also, all stereochemistry has vanished ! ! !
The catalyst goes from having 5 bonds to various things, to 6 with the bonds shown coming off the ruthenium atom like quills from a porcupine. Surely the disposition of the bonds in space must be known? Doesn’t it matter? Ditto for the metathesis catalysts on 1025. This is the way things were drawn (if they were drawn at all), in my orgo book of 54 years ago — English and Cassidy.