Tag Archives: Donald Trump

The New York Times Parodies itself

I have a conservative friend who is becoming increasingly exercised by what he regards as the antiTrump bias of the Times. I’ve told him to calm down as the Times was turning into a parody of its former self. Today the NYT obliged by doing just that.

Here’s what so exercised my friend in today’s Times (19 Feb ’17). “For $200,000, a Chance to Whisper in Trump’s Ear”, Membership at Mar-a-Lago Gives Titans Easier Access to Political Power.” This appeared on the front page taking up the twomost right columns above the fold. All of page 13 inside is devoted to the article.

Here’s how the Times parodied itself “Around the World by Private Jet: Cultures in Transformation ” This took up the entire back page of the Style Section (New England Edition at Least) “Privately chartered Boeing 757 26 day/9 countries/50 travelers/$135,000” You will ride with 5 members of the Times staff (lilywhite) — Arthur O. Sulzberger Jr. Alan Riding, Nicholas Kristof, Elaine Sciolino and Elizabeth Bumiller. You will not have to share the air with the Times’ minority editorial contributors, Charles Blow (Black) and Ross Douhat (Conservative). They don’t appear to have a Latino.

Imagine the joy of access for the cut rate price of 135K (who said the Times didn’t care about the little man), while cruising at 35,000 feet exuding both virtue and carbon dioxide.

Here’s part of what my friend had to say about the article (unfortunately he doesn’t blog (he should ) so I can’t supply a link).

Back in the early 18th Century William Congreve wrote:

” Heaven has no rage like love to hatred turned
Nor hell a fury like a woman scorned”

You would think he was talking about the venerable “Gray LADY”, aka New York Times. Indeed the paper has jettisoned any pretense of professional journalistic ethics – any pretense of journalism purpose. A week after the election, after flagrantly shilling for Clinton and smearing Trump in previous months, the editor of the Times issued in writing to the papers readers an apology of sorts by admitting the paper had lost its way and promised to return to reporting news. Evidently atonement to its readers is in the words not the performance. The Gray Lady is profoundly stunned by the rejection by most of the country of the paper’s vision of how the world should be.

—-

Since the election the scorned and enraged Gray Lady has fill page after page , day after day , with disgrace as represented by the article below. The paper has flooded us with conjecture about things that have not happened and gossip of any sort that could denigrate and damage Trump.

The relentless attacks on Trump and his playing golf with dangerous cohorts etc is in marked contrast to how it suppressed any conjecture about Obama’s rise through the notoriously crooked Chicago political machine. Not a whisper of how he was dependent on other graduates of the Chicago cesspool, such as Axelrod and Jarrett. There was dismissal of Obama’s friendship with Ayers, a principal in a murderous urban terrorist group.

The august “paper of record” never conjectured how Obama could spent 20 years listening to Rev. Wright vicious racist rants and kept listening to them, but later said he hardly knew the man.

One final thought — could this be fake news, an ad bought by the Koch brothers to embarrass the Times. Possible, but unlikely.

It all depends on whose ox is being gored

The following article appeared in the New York Times 19 October 2016. The following paragraph begins a direct, continuous, unedited quote from the start of the article. Subsequently, the article discusses other matters brought up in the debate — here’s the link for the whole thing — https://www.nytimes.com/2016/10/20/us/politics/presidential-debate.html?_r=0. The times they are a’changin’ aren’t they?

“In a remarkable statement that seemed to cast doubt on American democracy, Donald J. Trump said Wednesday that he might not accept the results of next month’s election if he felt it was rigged against him — a stand that Hillary Clinton blasted as “horrifying” at their final and caustic debate on Wednesday.

Mr. Trump, under enormous pressure to halt Mrs. Clinton’s steady rise in opinion polls, came across as repeatedly frustrated as he tried to rally conservative voters with hard-line stands on illegal immigration and abortion rights. But he kept finding himself drawn onto perilous political territory by Mrs. Clinton and the debate’s moderator, Chris Wallace.

He sputtered when Mrs. Clinton charged that he would be “a puppet” of President Vladimir V. Putin of Russia if elected. He lashed out repeatedly, saying that “she’s been proven to be a liar on so many different ways” and that “she’s guilty of a very, very serious crime” over her State Department email practices. And by the end of the debate, when Mrs. Clinton needled him over Social Security, Mr. Trump snapped and said, “Such a nasty woman.”

Mrs. Clinton was repeatedly forced to defend her long service in government, which Mr. Trump charged had yielded no real accomplishments. But she was rarely rattled, and made a determined effort to rise above Mr. Trump’s taunts while making overtures to undecided voters.

She particularly sought to appeal to Republicans and independents who have doubts about Mr. Trump, arguing that she was not an opponent of the Second Amendment as he claimed, and promising to be tougher and shrewder on national security than Mr. Trump.

But it was Mr. Trump’s remark about the election results that stood out, even in a race that has been full of astonishing moments.

Every losing presidential candidate in modern times has accepted the will of the voters, even in extraordinarily close races, such as when John F. Kennedy narrowly defeated Richard M. Nixon in 1960 and George W. Bush beat Al Gore in Florida to win the presidency in 2000.

Mr. Trump insisted, without offering evidence, that the general election has been rigged against him, and he twice refused to say that he would accept its result.

“I will look at it at the time,” Mr. Trump said. “I will keep you in suspense.”

“That’s horrifying,” Mrs. Clinton replied. “Let’s be clear about what he is saying and what that means. He is denigrating — he is talking down our democracy. And I am appalled that someone who is the nominee of one of our two major parties would take that position.”

Mrs. Clinton then ticked off the number of times he had deemed a system rigged when he suffered a setback, noting he had even called the Emmy Awards fixed when his show, “The Apprentice,’’ was passed over.

“It’s funny, but it’s also really troubling,” she said. “That is not the way our democracy works.”

Mrs. Clinton also accused Mr. Trump of extreme coziness with Mr. Putin, criticizing him for failing to condemn Russian espionage against her campaign’s internal email.

When Mr. Trump responded that Mr. Putin had “no respect” for Mrs. Clinton, she shot back, in one of the toughest lines of the night: “That’s because he’d rather have a puppet as president of the United States.”

“No puppet, no puppet,” Mr. Trump sputtered. “You’re the puppet.” He quickly recovered and said, “She has been outsmarted and outplayed worse than anybody I’ve ever seen in any government, whatsoever.”

There’s more — but the above is a direct continuous unedited quote from the article

One good thing about Trump’s election (maybe two)

Two comments on the election then back to some neuropharmacology and neuropsychiatry which will likely affect many of you (because of some state ballot initiatives).

First: Over the years I’ve thought the mainstream press has become increasingly biased toward the left (not on the editorial page which is fine) but in supposedly objective reporting. Here are just two post election examples

#1 Front page of the New York Times 9 Nov — the first sentence from something they characterize as ‘News Analysis’

““Donald John Trump was elected the 45th president of the United States on Tuesday in a stunning culmination of an explosive, populist and polarizing campaign that took relentless aim at the institutions and long-held ideals of American democracy.”

#2 Front page of the New York Times 10 Nov — more ‘News Analysis’ — Here’s the lead “Populist Fury may Backfire”. Don’t they wish.

I’ll never complain about this sort of thing again (well at least not for four years). Why? Because I’ve been reading the Wall Street Journal, The New York Times, The Nation and the National Review for probably 50 years, and Trump as the antiChrist is the first thing I’ve ever seen all four agree on. This biased coverage simply no longer matters. If it did, Trump would have lost and lost big. This just confirms the marked loss of credibility that the mainstream media has suffered.  People aren’t as dumb as the elites think they are.

Second: Political correctness and attempts to control speech so as not to offend lost big. That’s very good for us all right and left (although the impetus for speech control has switched to the left from the right over the past 56 years) — see https://luysii.wordpress.com/2015/11/22/from-banned-in-boston-to-banned-in-berkeley-in-55-years/

What do the state ballot initiatives have to do with neuropharmacology? Just this. Voters in California, Massachusetts and Nevada approved recreational marijuana initiatives Tuesday night, and several other states passed medical marijuana provisions.

I don’t think this is good. One of the arguments in its favor is that marihuana isn’t as bad as alcohol, which may be true, but if marihuana isn’t all good why add it to the mix? We don’t have a good handle on marihuana use, but it is likely to increase if it’s legal.

Why do I think this is bad (particularly for adolescents)? It is likely that inhibiting synaptic feedback isn’t a good thing for a brain which is pruning a lot of them (which happens in normal adolescence as the thickness of the cerebral cortex shrinks).

There have been many explanations for the decline in College Board Scores over the years. This has led to their normalization (so all our children are above average). If you’re a correlation equals causation fan, plot the decline vs. time of atmospheric lead. It is similar to the board scores decline. Or you can plot 1/adolescent marihuana use vs. time and get a similar curve. The problem, of course, is that we have no accurate figures for use.

Here’s the science — it’s an old post, but little has happened since it was written to change the science behind it

Why marihuana scares me

There’s an editorial in the current Science concerning how very little we know about the effects of marihuana on the developing adolescent brain [ Science vol. 344 p. 557 ’14 ]. We know all sorts of wonderful neuropharmacology and neurophysiology about delta-9 tetrahydrocannabinol (d9-THC) — http://en.wikipedia.org/wiki/Tetrahydrocannabinol The point of the authors (the current head of the Amnerican Psychiatric Association, and the first director of the National (US) Institute of Drug Abuse), is that there are no significant studies of what happens to adolescent humans (as opposed to rodents) taking the stuff.

Marihuana would the first mind-alteraing substance NOT to have serious side effects in a subpopulation of people using the drug — or just about any drug in medical use for that matter.

Any organic chemist looking at the structure of d9-THC (see the link) has to be impressed with what a lipid it is — 21 carbons, only 1 hydroxyl group, and an ether moiety. Everything else is hydrogen. Like most neuroactive drugs produced by plants, it is quite potent. A joint has only 9 milliGrams, and smoking undoubtedly destroys some of it. Consider alcohol, another lipid soluble drug. A 12 ounce beer with 3.2% alcohol content has 12 * 28.3 *.032 10.8 grams of alcohol — molecular mass 62 grams — so the dose is 11/62 moles. To get drunk you need more than one beer. Compare that to a dose of .009/300 moles of d9-THC.

As we’ve found out — d9-THC is so potent because it binds to receptors for it. Unlike ethanol which can be a product of intermediary metabolism, there aren’t enzymes specifically devoted to breaking down d9-THC. In contrast, fatty acid amide hydrolase (FAAH) is devoted to breaking down anandamide, one of the endogenous compounds d9-THC is mimicking.

What really concerns me about this class of drugs, is how long they must hang around. Teaching neuropharmacology in the 70s and 80s was great fun. Every year a new receptor for neurotransmitters seemed to be found. In some cases mind benders bound to them (e.g. LSD and a serotonin receptor). In other cases the endogenous transmitters being mimicked by a plant substance were found (the endogenous opiates and their receptors). Years passed, but the receptor for d9-thc wasn’t found. The reason it wasn’t is exactly why I’m scared of the drug.

How were the various receptors for mind benders found? You throw a radioactively labelled drug (say morphine) at a brain homogenate, and purify what it is binding to. That’s how the opiate receptors etc. etc. were found. Why did it take so long to find the cannabinoid receptors? Because they bind strongly to all the fats in the brain being so incredibly lipid soluble. So the vast majority of stuff bound wasn’t protein at all, but fat. The brain has the highest percentage of fat of any organ in the body — 60%, unless you considered dispersed fatty tissue an organ (which it actually is from an endocrine point of view).

This has to mean that the stuff hangs around for a long time, without any specific enzymes to clear it.

It’s obvious to all that cognitive capacity changes from childhood to adult life. All sorts of studies with large numbers of people have done serial MRIs children and adolescents as the develop and age. Here are a few references to get you started [ Neuron vol. 72 pp. 873 – 884, 11, Proc. Natl. Acad. Sci. vol. 107 pp. 16988 – 16993 ’10, vol. 111 pp. 6774 -= 6779 ’14 ]. If you don’t know the answer, think about the change thickness of the cerebral cortex from age 9 to 20. Surprisingly, it get thinner, not thicker. The effect happens later in the association areas thought to be important in higher cognitive function, than the primary motor or sensory areas. Paradoxical isn’t it? Based on animal work this is thought to be due pruning of synapses.

So throw a long-lasting retrograde neurotransmitter mimic like d9-THC at the dynamically changing adolescent brain and hope for the best. That’s what the cited editorialists are concerned about. We simply don’t know and we should.

Addendum 11 Nov ’16:  From an emerita nonscientific professor friend of my wife. “Much of the chemistry/pharmacology etc. is way beyond me, but I did get the drift of the conversation about marihuana and am glad to now have even a simplified concept of what it does to the brain. Having spent the last 20 years working with undergraduate and graduate students, I’ve seen first hand the decline in cognitive ability.” 

Scary ! ! ! !

Having been in Cambridge when Leary was just getting started in the early 60’s, I must say that the idea of tune in turn on and drop out never appealed to me. Most of the heavy marihuana users I’ve known (and treated for other things) were happy, but rather vague and frankly rather dull.

Unfortunately as a neurologist, I had to evaluate physician colleagues who got in trouble with drugs (mostly with alcohol). One very intelligent polydrug user MD, put it to me this way — “The problem is that you like reality, and I don’t”.

Trump

Too late to start an enormous post on huntingtin, the protein mutated in Huntington’s chorea. Coming soon. Sorry. But consider this: If Trump wins the presidency it will be a remarkable demonstration of the the lack of power of the press. When have the following agreed on an issue — New York Times, Wall Street Journal, National Review, The Nation, Weekly Standard, etc. etc. They all hate Trump editorially and by their selection of articles and phraseology. I’ve never seen anything like it.

Remarkable times. There is tremendous dissatisfaction with the way things are going. Bernie taps into it as well.

If a Harvard professor said it, it can’t be wrong

Harvard professors are always right, so here’s a quote from one about immigrants.

” It may be doubted, as a gen­eral rule, whether the young Irish-American is a better or safer citizen than his parent from Cork. He can read, but he reads nothing but sensation stories and scandalous picture-papers, which fill him with preposterous notions and would enfeeble a stronger brain than his and debauch a sounder conscience. He is generally less industrious than his sire, and equally careless of the public good.”

This is Francis Parkman (Harvard 1844) Professor of Horticulture at Harvard writing in 1878.

Got that Donald !