Homework assignment for the protein chemist

As an ace protein chemist you are asked to design two proteins, both intrinsically disordered which form a tight complex with a picoMolar dissociation constant.  To make the problem ‘easier’ there is no need for specific amino acid interactions between the proteins.  To make the problem harder, even in the tight complex formed, the two proteins remain intrinsically disordered.

Hint: ‘nature’, ‘evolution’, ‘God’ —  whatever you chose to call it, has solved the problem.

Answer in a few days.

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  • Peter S. Shenkin  On March 6, 2018 at 9:02 pm

    Well, hell, some of us read Derek Lowe…. Wish I hadn’t. I wonder if I’d-a gotten it.

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