Chapter III of “A Troublesome Inheritance” contains a lot of very solid molecular genetics, and a lot of unfounded speculation. I can see why the book has driven some otherwise rational people bonkers. Just because Wade knows what he’s talking about in one field, doesn’t imply he’s competent in another.
Several examples: p. 41 “”Nonethless, it is reasonable to assume that if traits like skin color have evolved in a population, the same may be true of its social behavior.” Consider yes, assume no.
p. 42 “The society of living chimps can thus with reasonable accuracy stand as a surrogate for the joint ancester” (of humans and chimps — thought to be about 7 megaYears ago) and hence describe the baseline from which human social behavior evolved.” I doubt this.
The chapter contains many just so stories about the evolution of chimp and human societies (post hoc propter hoc). Plausible, but not testable.
Then follows some very solid stuff about the effects of the hormone oxytocin (which causes lactation in nursing women) on human social interaction. Then some speculation on the ways natural selection could work on the oxytocin system to make people more or less trusting. He lists several potential mechanisms for this (1) changes in the amount of oxytocin made (2) increasing the number of protein receptors for oxytocin (3) making each receptor bind oxytocin more tightly. This shows that Wade has solid molecular biological (and biological) chops.
He quotes a Dutch psychologist on his results with oxytocin and sociality — unfortunately, there have been too many scandals involving Dutch psychologists and sociologists to believe what he says until its replicated (Google Diederik Stapel, Don Poldermans, Jens Forster, Markus Denzler if you don’t believe me). It’s sad that this probably honest individual is tarred with that brush but he is.
p. 59 — He notes that the idea that human behavior is solely the result of social conditions with no genetic influence is appealing to Marxists, who hoped to make humanity behave better by designing better social conditions. Certainly, much of the vitriol heaped on the book has come from the left. A communist uncle would always say ‘it’s the system’ to which my father would reply ‘people will corrupt any system’.
p. 61 — the effect of mutations of lactose tolerance on survival on society are noted — people herding cattle and drinking milk, survive better if their gene to digest lactose (the main sugar in milk) isn’t turned off after childhood. If your society doesn’t herd animals, there is no reason for anyone to digest milk after weaning from the breast. The mutations aren’t in the enzyme digesting lactose, but in the DNA that turns on expression of the gene for the enzyme (e.g. the promoter). Interestingly, 3 separate mutations in African herders have been found to do this, and different from the one that arose in the Funnel Beaker Culture of Scandinavia 6,000 yers ago. This is a classic example of natural selection producing the same phenotypic effect by separate mutations.
There is a much bigger biological fish to be fried here, which Wade doesn’t discuss. It takes energy to make any protein, and there is no reason to make a protein to help you digest milk if you aren’t nursing, and one very good reason not to — it wastes metabolic energy, something in short supply in humans as they lived until about 15,000 years ago. So humans evolved a way not to make the protein in adult life. The genetic change is in the DNA controlling protein production not the protein itself.
You may have heard it said that we are 98% Chimpanzee. This is true in the sense that our 20,000 or so proteins are that similar to the chimp. That’s far from the whole story. This is like saying Monticello and Independence Hall are just the same because they’re both made out of bricks. One could chemically identify Monticello bricks as coming from the Virginia piedmont, and Independence Hall bricks coming from the red clay of New Jersey, but the real difference between the buildings is the plan.
It’s not the proteins, but where and when and how much of them are made. The control for this (plan if you will) lies outside the genes for the proteins themselves, in the rest of the genome. The control elements have as much right to be called genes, as the parts of the genome coding for amino acids. Granted, it’s easier to study genes coding for proteins, because we’ve identified them and know so much about them. It’s like the drunk looking for his keys under the lamppost because that’s where the light is.
p. 62 — There follows some description of the changes of human society from hunter gathering, to agrarian, to the rise of city states, is chronicled. Whether adaptation to different social organizations produced genetic changes permitting social adaptation or were the cause of it isn’t clear. Wade says “changes in social behavior, has most probably been molded by evolution, through the underlying genetic changes have yet to be identified.” This assumes a lot, e.g. that genetic changes are involved. I’m far from sure, but the idea is not far fetched. Stating that genetic changes have never, and will never shape society, is without any scientific basis, and just as fanciful as many of Wade’s statements in this chapter. It’s an open question, which is really all Wade is saying.
In defense of Wade’s idea, think about animal breeding as Darwin did extensively. The Origin of Species (worth a read if you haven’t already read it) is full of interchanges with all sorts of breeders (pigeons, cattle). The best example we have presently are the breeds of dogs. They have very different personalities — and have been bred for them, sheep dogs mastifs etc. etc. Have a look at [ Science vol. 306 p. 2172 '04, Proc. Natl. Acad. Sci. vol. 101 pp. 18058 - 18063 '04 ] where the DNA of variety of dog breeds was studied to determine which changes determined the way they look. The length of a breed’s snout correlated directly with the number of repeats in a particular protein (Runx-2). The paper is a decade old and I’m sure that they’re starting to look at behavior.
More to the point about selection for behavioral characteristics, consider the domestication of the modern dog from the wolf. Contrast the dog with the chimp (which hasn’t been bred).
[ Science vol. 298 pp. 1634 - 1636 '02 ] Chimps are terrible at picking up human cues as to where food is hidden. Cues would be something as obvious as looking at the containing, pointing at the container or even touching it. Even those who eventually perform well, take dozens of trials or more to learn it. When tested in more difficult tests requiring them to show flexible use of social cues they don’t
This paper shows that puppies (raised with no contact with humans) do much better at reading humans than chimps. However wolf cubs do not do better than the chimps. Even more impressively, wolf cubs raised by humans don’t show the same skills. This implies that during the process of domestication, dogs have been selected for a set of social cognitive abilities that allow them to communicate with humans in unique ways. Dogs and wolves do not perform differently in a non-social memory task, ruling out the possibility that dogs outperform wolves in all human guided tasks.
All in all, a fascinating book with lots to think about, argue with, propose counterarguments, propose other arguments in support (as I’ve just done), etc. etc. Definitely a book for those who like to think, whether you agree with it all or not.